SAMeLO

S-ADENOSYL-L-METHIONINE

SAMeLO

S-ADENOSYL-L-METHIONINE
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1 bottle
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$88.99 $75.64 per bottle
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2 bottles
delivery every 2 months
$88.99 $72.97 per bottle
SAVE 18%
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3 Bottle
One time supply
$29.66 /bottle
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veterinarian
formulated

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made with
natural ingredients

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nutritionist
approved

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chewable
tablets

S-ADENOSYL-L-METHIONINE

S-ADENOSYL-L-METHIONINE

Supports antioxidant activity, helps maintain normal liver function, and promotes healthy cellular processes. This supplement is designed to provide safe and effective daily liver support.

CLINICALLY
RESEARCHED
RESULTS

80%

Clinical studies have shown that SAMe supplementation can optimize liver enzyme levels in up to 80% of dogs with certain liver conditions, supporting hepatic function.

Research highlights SAMe for its role in promoting antioxidant activity, aiding detoxification, and supporting liver cell rejuvenation during stress or illness.

VISIBLE RESULTS YOU CAN SEE AND FEEL

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supports healthy liver function and detoxification

promotes antioxidant activity to protect liver cells

helps maintain normal metabolic processes and energy levels

reinforces long-term liver health for dogs of all ages

Progress Calendar

month-by-month progress

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Initial Support Begins

A POWERFUL INGREDIENTSAMe begins supporting antioxidant activity and healthy liver function, while antioxidants help reduce oxidative stress.

Early signs may include:

  • Better appetite and digestion
  • More energy and playfulness
  • More consistent hydration
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Noticeable Comfort & Balance

By now, antioxidant compounds and amino acids begin reinforcing cellular health, while palatable ingredients ensure consistent daily intake.

Pet parents often notice: 

  • Healthier weight and muscle tone
  • Brighter eyes and improved coat quality
  • More stable energy levels
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Full Results & Ongoing Wellness

Consistent daily use leads to long-term benefits:

  • Stronger liver function and detox capacity
  • Reduced risk of toxin buildup
  • Better overall vitality and comfort


Most dogs experience sustained wellness and noticeable improvement in daily energy and digestion.

  • 5 stars: 139 (70%)
  • 4 stars: 59 (30%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
S
Sharon C.
Same lq 225 for dogs

Reasonable cost when they have their sale! My dog needs me to break them up because she has small teeth but the cost is good. Plus that with the milk thistle helps bring her liver value down some .

V
Vera

This medicine helps my dog so much, I love this product!!

T
Terri A.
My dog loves them!

My dog thinks they are a treat and will eat it up as is! They have really seemed to help with his night time whining , as well as his joints. He is a much happier 12 year old now!

R
Robecca
I love giving this to my Sheltie

Our vet put my Sheltie on SAMe to help with complications from seizures and pancreatitis. I decided to give Coco and Luna a try, the value seemed good and the dosage was just right. While I love giving this to my Sheltie, she loves getting them. I tell her it's time for her happy good mood pills and when they are gone, she's still looking for more. I know they are helping her and I know this is a good quality product and I feel comfortable purchasing from this company.

P
P E.P.
My dog loves the taste.

My vet recommended this product for my dog. She told me it takes about 5weeks to kick in. We are in that time frame now. I plan to reorder.

c
caa48
LQ225

My dog is responding well with this medication. Good value

J
Jetengineman
Fountain of Youth

My Shihtzu was slowing down with age. She was getting UTIs, foggy brain, and Sundowner’s Syndrome. The vet recommended Sam-e. I purchased Coco and Luna, mostly for the great price point. What a surprise when within two weeks, my baby was showing signs of improvement! My mother’s 16 year old Min Pin started on Sam-e shortly after and Minnie showed the same great results. Thank you, Coco and Luna!

S
Sharon O.
This product works!

The Coco and Luna SAME LQ 255 for brain support and liver health honestly works.

K
Kathleen P.
Seems to be doing good.

Appears our dog likes the flavor. I am seeing more energy from my 14 year old. Going to the bathroom remains steady for her. She is getting older, but remains steady with her attention while taking the pills, so I like that.

S
Shelle12
Worth trying

Really helps both my senior dogs. They have more energy and less "senior fog" moments.

w
wadd02
Good

Good

V
V S.
great product so far

My dog love the flavor. Thinks it's a treat

R
Rolene
Dogs like these

Dog likes

C
Cyndi M.
Made a Miracle

I started my 14 yr old Jack Russell on these tablets two months ago. She was starting to pace at night and appear disoriented at times. She was also struggling with bloating and digestive issues. All of those are resolved and she acts like a 4 yr old instead of a 14 yr old. I don't know how much time we will have together BUT I do know she is living a much better life right now!

k
kris f.
Great product for your Pets mental health!

We noticed a decline in one of our dog's mental health, something we anticipated due to his age. Our Vet recommended several supplements for a variety of ailments he was experiencing. In particular a SAMe supplement. With so many products on the market, it was difficult to know which was best. But, my research led me to Coco and Luna's SAMe LQ 225. Since we starting use this product we have notice a vast improvement in our dogs health and he is starting to look and act like his old self again.

L
Logan H.
Old Dog is feeling great

Bought these for 13 year old Scottie that has had liver issues. First time trying this brand and dog seemed to not have some of the side effects of other similar tablets. We will definitely buy again.

D
Dan D.
Great deal on SamE for dogs

I was very happy with this product for my dog. The price is great. She likes the flavored tablets.

J
Janetann D.
Two dogs both like it

I like the product, the one negative is the pill is a little too hard for one of my dogs to chew but he is fine once I cut it up. Both dogs eat it in their food with no problem.

N
Navy M.C.
This stuff really works

I acquired an elderly Yorkie three years ago (she was 12) because when her owner died I was told that if she went to the shelter she would be euthanized. She had bad teeth, bad hips, Cushings, and a damaged trachea. After addressing her dental issues, and changing her diet, it was recommended that I put her on SAMe for her Cushing's Syndrome. This product has been phenomenal! Despite her arthritis, she bounces now, and just seems to be so much happier all the time. Her constant drinking/peeing has decreased, she has even lost some weight. I truly believe that this product is partially responsible for the little bit still being with us. And she is not in any danger of going anywhere soon. Thank you Coco and Luna

D
Diane S.
This product has worked to enhance my dog's Liver enzymes.

My 13 year old Golden Doodle Leah Lu has been having some liver enzyme issues and has been on this supplement for several months and has shown considerable improvement.

R
ROB675
Product Really Works

Bought this product to help my dog Bear stave off Canine Cognitive Disorder (CCD). Noticed a significant improvement after 4 days of giving Bear 1 tablet with each AM & PM feeding. After 1 month no sign of CCD is apparent although I realize that there is no cure for CCD. Bear loves the bacon flavor & there have been no visible side effects. I highly recommend this supplement!

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JENNIFER M.B.
Valuable product

My dog who was diagnosed with CCD is on this and she loves it. It seems to be helping her stay mentally acute and her mobility is doing well also. Definitely worth the purchase!

E
Emily B.
Just what my dog needed!

My dog has liver issues and it’s hard to find a liver supplement that is affordable. I was so happy to see Coco and Luna had a product that is affordable! I also use their turmeric and my dogs love it!

j
joshua m.w.
This is the golden ticket 🙋🏻💥💥💥

Well my canine is 15 years old And came down with K9 CCD. He Used to stand in the corner and just stare also he would trap himself under chairs and not be able to get out And also he was very nervous and with lots of anxiety panting for hrs. Where on our 2nd bottle in almost finished I have my old dog back. He is no longer doing those things that described As he is much more alert in functionable like a normal canine. Thank you so very much for your product and not sure if he would be alive without it God-bless you🕊❤

J
Jeepfixitman
Well worth it!!!!!

We have a Pomeranian with kidney issues, this shows the same results as other items we've tried at a great cost and with a flavor that he takes without the fight!!!!!

A
Amazon C.
Happy with products

Great product and great service.

A
Anne R.
I recommend this product

My dog’s Veterinarian recommended that I try this product to help rid toxins in his liver from daily use of Rimadyl (for inflammation). I have noticed a difference in my dog’s energy

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Sharon A.G.
Great product

Gave to my elderly dog who had a stroke. He was very anxious and confused keeping us up through the night. Took about a week and he settled down. Like magic he's sleeping through the night. Highly recommend.

M
Mike G.
Great product!!!

We love the product! It has really helped our dogs

M
MCH
Recommend!

My dog loves these! Takes them like a treat. She is almost through her first bottle and I have noticed an increase in her energy and activity levels. I plan to continue to buy them.

J
JACK W.
Good product

My dog took it with no problem. Good value

A
Amazon C.
Great product

Excellent product. Recommended by my Vet.